You know the paradox: people in red states gladly accept benefits from a welfare state that was created by Democrats, but consistently vote for Republicans who want to slash those benefits, because GOP candidates respect their culture, promise them their old jobs back, and tell them to blame the illegal immigrants for their problems. Most of that platform is a scam, but it works.
So what can the federal government (at least, when it’s open) do to assist these people? It is primarily a state and local responsibility, unless you assume that tariffs are the answer, which they aren’t. However, Washington can make sure that adequate funds are provided for education and infrastructure in depressed areas, and it would help low-skilled workers if the burden of financing the welfare state were shifted to the country as a whole, not employers and employees.