In this scenario, Edward VI lives to a ripe old age and has a male heir. Mary and Elizabeth never reign; in fact, it is possible that Mary is executed at some point. The king pursues a more aggressively Protestant foreign policy than Elizabeth did. Relations with Parliament are somewhat less fraught, as there are no issues with the succession or religion. Catholicism withers, but does not die.
The real question with this counterfactual is whether Edward marries the Queen of Scots after the death of her French husband. The timing suggests not; Edward probably would have been married before that opportunity presented itself. England and Scotland would ultimately have been united, but in a different way.